tirzepatide in bodybuilding to obesity (~300lbs) to now on (-66lbs, to ~231lbs, 163cm) : r/Zepbound Ozempic bodybuilders push for open

BioMed Research International (2015) 3

Effects of pyrroloquinoline quinone disodium salt intake on the serum cholesterol levels of healthy Japanese adults

Semaglutide demonstrates significantly larger weight reductions in clinical trials, with patients achieving 15% to 22% body weight loss over 68 weeks in the STEP trials

Source: Jastreboff et al., NEJM 2023 TRIUMPH-4 Phase 3 (68 weeks, 445 participants) Phase 2 Type 2 Diabetes Trial (36 weeks, 281 participants) In the type 2 diabetes population, weight loss was lower than in the obesity trial which is consistent with the pattern seen across all GLP-1 drugs

Common side effects include gastrointestinal issues, such as nausea, vomiting, diarrhea, and constipation

Slowing your titration schedulestaying at each dose level 12 weeks longerallows your GI system to adapt