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Beyond its ability to increase IGF-1 levels (discussed later), MK677 may be useful in thwarting both the normal effects of aging on the brain as well as pathological changes due to disease all because it improves sleep quality
One possibility is that the IGF-IR/IGF-IR ratio can dictate the different outcome
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Whilst the concentration of melatonin used in vitro far exceeds that found in vivo , in vitro conditions lead to the rapid degradation of melatonin reducing its concentration swiftly over a 24h period
(PubMed) Teather LA, Wurtman RJ
In fact, promising research has found that it may positively impact brain function and cognition
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