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The analysis should be thoroughly documented and discussed with patients as part of the informed consent process
It represents a minimal loss that does not significantly affect your dose
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It slows gastric emptying so food stays in the stomach longer
Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet
These experiments provided a rationale for later mouse studies but did not establish a human fat-loss effect
