Reported plasma levels of phenformin after 50-100 mg of phenformin uptake in patients are ~1.7 M 67 , while tissue concentrations have not been assessed but are expected to be much higher as reported in animal models 68
In this study, strontium (SrHA) and zinc (ZnHA) were used on the surface to replace Ca 2+ in HA
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In addition, confirming the efficacy of GSH treatment, a reduction in malondialdehyde, a marker of hepatic cell damage, was detected