10.2337/diabetes.53.suppl_3.S215 52
NASH caused hepatomegaly, fibrosis, and inflammation in all mice, with aged mice showing increased heart weight, left ventricular volumes, and subtle systolic and diastolic dysfunction, thus NASH tends to worsen age-related cardiac dysfunction [37]
Indirect effects may be just as important
Phentermine is a powerful appetite suppressant that stimulates the production of epinephrine and norepinephrine
Some patients report slightly better appetite suppression when they inject in the evening, possibly because the medication's peak effects occur during their typical meal times the following days
The Discovery: Its Not Just the Weight Loss Using elegant mouse models, the researchers decoupled weight loss from drug action