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By starting with very low doses and titrating slowly, some practitioners believe patients may achieve metabolic benefits whilst minimising tolerability issues

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Initially, PYY(3-36) was highly regarded for its potent appetite-suppressing effects mediated by hypothalamic Y2 receptors, but increasing evidence suggests that both PYY forms participate in glucose homeostasis and insulin sensitivity through complex, often complementary mechanisms, offering new potential therapeutic targets for insulin-resistant diseases (4, 5)

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Executive summary of the KDIGO 2022 clinical practice guideline for diabetes management in chronic kidney disease: an update based on rapidly emerging new evidence