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It is used in research on energy metabolism and, in certain specific clinical contexts, under professional indication and supervision

Peer review Peer review information Nature Reviews Endocrinology thanks Steven Heymsfield, Luis Moreno and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

But for most, he says, there's an element of negative reinforcement

For men , the primary concern during weight loss is usually maintaining lean mass

CB-839, a GLS inhibitor that blocks the conversion of glutamine into glutamate, reduced the production of R-2-HG in AML cell lines and patient tissues harboring IDH1/2 mutations 123