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Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone

The glucagon-arm effects active hepatic fat oxidation and protection against the usual weight-loss-driven drop in resting metabolic rate fade in roughly the same window

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Role of the vagus nerve in the development and treatment of diet-induced obesity

This effect is mediated through the same GHS-R1a receptor but in hypothalamic neurons rather than pituitary somatotrophs

This specific analysis focused on data from more than 17,000 adults 45 years old or older from 41 different countries