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Shiimura et al., 2025), revealing that the ligand-binding pocket of the ghrelin receptor features a unique architecture referred to as a bifurcated pocket, comprising two distinct cavities
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It also compounds the risk of functional decline and bone density loss, which is the opposite of what a longevity-focused patient is working toward
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Research models suggest the combination maintains endocrine specificity, making it of interest to investigators focused on isolating GH-axis effects without confounding stress-hormone elevations
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