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TMQ0153 significantly increased the ROS levels in MV4-11 and U937 cells (Fig

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Together, these observations suggest that at peak disease, lipid-laden ARG1 + Mdcs within demyelinating lesions may deprive the local microenvironment of arginine, thereby instigating oxidative stress and lipid peroxidation

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For example, choline and carnitine are both quaternary ammonium compounds and both important for brain development [110, 111]