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So, it isn't the fact that, like, there is nothing in anything that exists on planet Earth

Biochim Biophys Acta (BBA) - Biomembranes 1788:20802083

Because the liver is responsible for filtering everything you ingest, it is constantly exposed to oxidative pressure

(They think this is why there is a window- once the receptors are lost, starting estrogen cannot resurrect them) One study showed a 26% reduction in dementia when HRT was started at 48.7 yo, vs an Increased risk of dementia of 48% when started at age 76

A key mechanism involves stimulating cytokine secretion by immune cells

Effect on cytotoxic lymphocytes and natural killer cells