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Regular exercise, sufficient sleep, and lower stress levels also support glutathione production

In the case of bones, aging is associated with increased activity of osteoclasts, cells that break down bone tissue

This flexibility represents an important practical advantage, allowing patients to choose a schedule that best fits their lifestyle and daily routine

One speculation is that although adipocytes have reduced GPX4, adipocytes may be similar to some tumor cells, which still have a high level of GSH in their cells, so that although adipocytes are in an overall oxidative stress condition, the remaining GPX4 from GSH is still needed to neutralize large amounts of ROS and remove some of the lipid peroxides, resulting in differentiated adipocytes that are not or less affected by ferroptosis (81)

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Rawat S, Borkowski WJ Jr, Swick HM