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doi: 10.3389/fphar.2022.856111 Received 16 January 2022 Accepted 15 February 2022 Published 08 March 2022 Volume 13 - 2022 Edited by Giuseppe Paolisso, University of Campania Luigi Vanvitelli, Italy Reviewed by Stefano Ciardullo, University of Milano Bicocca, Italy Maria Rosaria Rizzo, University of Campania Luigi Vanvitelli, Italy Updates Copyright 2022 Pahud de Mortanges, Sinaci, Salvador, Bally, Muka, Wilhelm and Bano

The reduction in purine levels was associated with increased oxidative stress and endothelial dysfunction, both of which have been implicated in the pathophysiology of both ME/CFS and GWS (Furuhashi, 2020