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Although melanin itself provides protection against reactive oxygen species (ROS) and toxic free radicals, paradoxically, the biosynthesis of melanin itself generates ROS that may cause DNA damage

[PMID: 30291911] PubMed record related to this compound for laboratory literature review

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This produces tolerance subjects require progressively higher doses to maintain pigmentation, which increases off-target side effect risk

Higher doses or irregular administration may increase the likelihood of nausea and upset stomach

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