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It is important to note that Wegovy is started at a low dose and increases slowly over time to reduce side effects such as nausea

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Appetite changes often occur quite rapidly

Another critical challenge involves the lack of standardized research methodologies, including inconsistency in dosing strategies, routes of administration, treatment durations, and outcome measures

It points to GLP-1 receptors being stimulated throughout the body, including in the brain's appetite and nausea centers, and says that widespread activation combines with rapid changes in blood glucose and hydration status during early treatment

The rate of NAION diagnoses was compared across groups to identify potential connections between the medications and eye diagnoses