how does semaglutide promote weight loss Benefits of GLP-1 Semaglutide for Weight Loss: How

The simplest way to picture it: one pathway helps the body feel full, one helps it handle blood sugar and stored fuel, and one may push energy use up

& Mastorakos, G

Mechanism of Action Comparison# Retatrutide# Retatrutide (LY3437943) is a 39-amino acid peptide that simultaneously activates three metabolically important receptors: GLP-1 receptor : Enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes central satiety signaling GIP receptor : Potentiates insulin secretion, may improve beta-cell function, and contributes to adipose tissue metabolism Glucagon receptor : Increases hepatic glucose output acutely but chronically promotes hepatic fat oxidation, thermogenesis, and energy expenditure The glucagon receptor component distinguishes retatrutide from all other approved or late-stage metabolic peptides

Oct 30 2020;370(6516):557-564

The pancreas compensates by producing more insulin, but this overwork eventually exhausts beta cells responsible for insulin production

Peptide therapy is not an overnight switch