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Oral supplements have to pass through the digestive system and may not be absorbed efficiently, especially in people with gastrointestinal conditions like celiac, Crohns, or gastritis

This aligns with observed metabolic improvements in clinical trials, reinforcing the peptides role in supporting balanced energy utilization and metabolic efficiency

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Target engagement remains context dependent, and metabolic mediation would require direct testing in adipocytes, adipose tissue, and whole-body metabolic models

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A clinician can confirm the cause and choose the safest treatment path