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In addition, a meta-analysis of the HARMONY studies of albiglutide revealed that the risk of cardiovascular events was not significantly higher in subjects on albiglutide than in subjects on all other comparators including placebo and oral antidiabetic drugs such as glimepiride, insulin glargine, insulin lispro, liraglutide, pioglitazone, and sitagliptin [99]

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PlexusDx Precision Peptide Genetic Test identifies which patients are most likely to experience this adaptation early, allowing providers to proactively recommend dual-compound therapy rather than waiting weeks for resistance to develop

Excluding patients who already had ESRD, the results showed that LN patients not on GLP-1Ras were twice as likely to progress to ESRD or dialysis dependence within five years compared to those using GLP-1Ras (OR 2.35, 95% CI 1.39, 3.976)

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