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These include limited long-term safety data across diverse populations, insufficient understanding of mechanisms in neuropsychiatric and oncologic contexts, and suboptimal communication between clinicians and patients
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Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials
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A variety of evidence indicates that peripheral injection of GLP-1 analogues may act directly on the hypothalamus and hindbrain or the signal is transmitted to the hindbrain by vagal afferents (57)
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