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The research literature supports 28 days as the conservative recommendation with a reasonable safety margin

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Hu and Chen (2018) showed that MOTS-c increased the expression of alkaline phosphatase (ALP), a marker of early osteoblast maturation, bone gamma-carboxyglutamic-acid-containing proteins (BGLAP), and Runx2, a transcription factor important for osteoblast differentiation, using the CCK-8 assay compared to negative controls

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whereas cyanocobalamin does not have this effect (7)

Many people use this combination for skin brightening, pigmentation support, and overall skin health