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Dihexa, with its combined N-hexanoic-Tyr-Ile-(6) aminohexanoic amide structure, exhibited a significantly extended half-life of 335.5 9.5 min, confirming that both N- and C-terminal modifications are effective strategies for improving metabolic stability [2]

doi: 10.1038/s41598-018-24240-2 295 PitaksaleeRBurskaANAjaibSRogersJParmarRMydlovaKet al

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Unlike synthetic Wnt agonists, which can create unwanted off-target stimulation, the tripeptide appears to nudge Wnt signaling within a biological operating range

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