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This work has been supported by NIH F31HD100124 (G.M.), NIH 1DP2HD091949-01 (S.S.H.), Open Philanthropy Grant 2019199327 (5384) (S.S.H.), NIH R01AR073226 (S.S.), NIH R35GM148351 (A.S.), NIH R01DC016065 (H.Z.), Howard Hughes Medical Institute (X.C.) and Gorden and Betty Moore Foundation (B.M.)

When clinicians talk about peptides that support mood, they are usually referring to compounds that influence brain signaling, stress hormones, or neuroplasticity, the brain's ability to adapt and form new connections

This peptide plays a critical role in tissue regeneration, inflammation modulation, and cellular migration

Preparation Condition 4 (EDTA 4 o C deproteinization): Storage at 80 o C prevents enzymatic degradation of GSH We included EDTA-treated plasma stored at 4 o C (Preparation Condition 4) as a positive control for enzymatic processes that may lead to degradation of GSH during sample storage

Serum was collected from each patient and donor and used for the isolation of RNA and quantification of cytokines