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2 The adjuvant activity of KL1 was consistent across compound sources

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Glucagon receptor activation increases your body's resting metabolic rate (you burn more calories at rest) and promotes lipolysis (the breakdown of stored fat into fatty acids that can be used for energy)

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Not only tirzepatide displayed a 20-fold lower potency in cAMP generation compared with native GLP-1, but also showed a signaling bias towards cAMP instead of beta-arrestin recruitment [39, 42]