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GLP-1 medications can reduce saliva production, which makes it easier for bacteria to grow and cause dental problems

This disease cluster encompasses three main subtypes: ossification of the posterior longitudinal ligament (clinically termed OPLL), ossification of the ligamentum flavum, and other ossified adjacent spinal support structures

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Eye-area formulations commonly use 2% concentrations

In the TRIUMPH-4 trial , published by Eli Lilly in December 2025, participants taking the 12 mg dose lost an average of 28.7% of their body weight at 68 weeks , and WOMAC pain scores were reduced significantly