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Antimelanogenic activity of hydrocoumarins in cultured normal human melanocytes by stimulating intracellular glutathione synthesis

National Library of Medicine: Pub Chem, L-Selenomethionine

Two additional substitutions further enhance the in vivo activity of efruxifermin: A180E, which increases affinity for KLB, and L98R, which decreases aggregation (238)

However, neither directly addresses nausea and should not be used routinely without specific indication

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