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2.3 Secondary bile acids The biosynthesis of secondary bile acids relies on a coordinated liver synthesisgut microbiota conversion mechanism: the liver first utilizes cholesterol 7-hydroxylase to catalyze the conversion of cholesterol into primary bile acids (e.g., cholic acid and chenodeoxycholic acid)

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(141) found that TSF treatment reduced serum LDL-C, TC and TG levels in db/db mice, while HDL-C levels had no significant effect