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Direct mechanisms of tirzepatide on cardiovascular health Although the precise mechanism by which tirzepatide could benefit HF is not known, several potential pathways have been suggested: Anti-inflammatory effects Patients with T2DM experience increased levels of hyperinsulinemia, hyperglycemia, and insulin resistance

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93 Additionally, tirzepatide, a dual GIP/GLP-1 receptor agonist, has gained prominence following USFDA approval in 2023 for weight management in adults with obesity or overweight and has demonstrated robust efficacy in RCTs