As there is no meaningful expression of GLP-1 receptors on hepatocytes, the major effect of GLP-1 agonists on MASH is likely to be indirect and may be related to a reduction in calorie intake, body weight and insulin resistance, all of which would lead to reduced liver lipid accumulation and hepatic inflammation 7,8
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Net social value and rates of return Substantial attention has been focused on the cost implications of GLP-1 treatment
It modulates inflammatory responses in the gut
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