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A.WalkerC
A structural explanation for these findings was provided from our previous cryo-EM structures of CT(Pro32) and rAmy(Tyr37)-bound AMYRs structures where the bulky phenolic side chain of Y37 rAmy forms perpendicular stacking interactions with W79 ECD 15 , and additional interactions with the respective RAMP protomer that are likely important for selectivity of rAmy for AMYRs over CTR
elastin and collagen
The compound distributes preferentially to metabolically active organs, showing highest concentrations in the kidneys and liver, followed by the stomach wall, thymus, spleen, and intestines
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