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A broader investigation into alternative regulatory modalities, such as ligand-dependent cytoplasmic sequestration or post-translational modifications, could provide new insights into nuclear receptor biology and help address the challenges of deorphanization

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Besides, those COVID-19 patients with significantly lower serum iron concentrations and transferrin levels are commonly anemic, indicating a potential inverse relationship between serum iron levels and the severity of COVID-19

Baraska A, Woniak A, Mokra K, Michaowicz J