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Clinical studies in humans with HE have only been performed by a few groups to date

Early rapid loss doesn't always predict long-term outcomes

Blood Pressure Reductions Participants on the 12mg dose experienced a 14.0 mmHg reduction in systolic blood pressure a clinically meaningful decrease that could translate to reduced cardiovascular events

Gastroparesis can be a complication of diabetes that is related to long-standing or poorly controlled disease, the agency added, further complicating the ability to determine what role the drugs played in the reported events. For its part, Ozempic and Wegovy creator Novo Nordisk defended its buzzy drugs to CNN , noting that abdominal changes are to be expected

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The real question isn't, "Will it work?" The only question that truly matters is, "Can I actually stick to it?" No matter how amazing a plan seems, and no matter how many influencers are talking about it, if your plan isn't something you enjoy and look forward to, you simply wont stick to it