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The reduced incretin effect in type 2 diabetic patients is much more closely related to the losses in insulinotropic activity of GIP, which are typical of this condition, and less so to those related to GLP-1 [64]

It's important to follow the dosing instructions carefully and use the provided measuring device to ensure the correct amount is taken

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however, older individuals also tend to have more pre-existing medical conditions that can increase the risk of side effects or complications

Combined with metabolic labs (fasting glucose, insulin, lipids), genetic insights can inform whether semaglutide, tirzepatide, or alternative approaches align with a patient's biology