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Description

Hum Exp Toxicol 26(6):499507

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In the retatrutide Phase 2 trial (Jastreboff et al., NEJM 2023), many participants found that symptoms such as diarrhoea, nausea, and abdominal discomfort improved after the initial weeks at a given dose, consistent with experience seen with licensed GLP-1 receptor agonists

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At the start of the study they weighed about 255 pounds, on average

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The decline in T-cell functionality with aging, a widely documented phenomenon, is linked to a reduced efficacy of anti-OX40 immunotherapy in murine models

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