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Pharmacokinetics of tirzepatide demonstrated dose proportionality over the wide dose range, with C max of 180 nM in individuals treated with one dose of 8 mg and a C max of 260 nM with 15 mg/week dose in the clinical study, exceeding the EC50 values for GIPR and GLP-1R activations by approximately 10,000-fold and 250-fold, respectively (63)

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The most common side effects relate to injection site reactions, occurring in approximately 5-10% of users

For systemic or musculoskeletal targets, injectable has a pharmacokinetic advantage

doi: 10.1093/JAS/SKAD281.208 36 DahlhoffC.DesmarchelierC.SailerM.FrstR

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