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Second, the anti-inflammatory effects observed in these studies occurred primarily in populations without autoimmune diseases, mostly people with type 2 diabetes or obesity
These two concomitant contrasting aspects of hyperactive mTORC1 may dynamically evolve during the clinical sequel of T2D, whereby the hyperplastic-hypertrophic initial feature yields progressively to an apoptosis outcome [131,132]
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Osteocalcin induces proliferation via positive activation of the PI3K/Akt, P38 MAPK pathways and promotes differentiation through activation of the GPRC6A-ERK1/2 pathway in C2C12 myoblast cells
Virology 210 , 441447 (1995)
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