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Tirzepatide is a once-weekly subcutaneous injection used for weight loss and blood sugar management

The metanalysis includes 5,323 patients (56-61 years) with T2D inadequately controlled (HbA 1c 7-10.5%), baseline BMI 23-45 kg/m 2 , mean diabetes duration of 9-12 years, and randomized to receive a GLP-1RA or GIP/GLP-1RA versus placebo in add on to basal insulin for at least 24 weeks (24-40 weeks)

SGLT2 inhibitors and GLP-1 agonists should be used as early as possible in the diabetes course to provide the most cardiac benefit, Joanna Khatib, MBBS, an endocrinology fellow at Tulane University School of Medicine, told Healio

The South Asian population is at higher risk of type 2 diabetes mellitus (T2DM) because of their genetic predisposition and lifestyle changes

doi: 10.1016/j.cbi.2008.07.009 111 SinghUDevarajSJialalI

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