A study published in May 2024 found that men with obesity who were taking semaglutide, the active ingredient in Ozempic and Wegovy, were actually at a slightly higher risk of erectile dysfunction than men with obesity who werent taking the drug
History suggests we should be cautious
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Absorption rates can vary slightly depending on: Injection site Abdominal injections may be absorbed slightly faster than thigh injections Injection depth Proper subcutaneous technique ensures consistent absorption Site rotation Regular rotation prevents lipohypertrophy (fatty lumps) that can affect absorption Renal and Hepatic Function The impact of kidney and liver function varies by medication: Exenatide is contraindicated if your kidney function is severely reduced (eGFR/CrCl below 30 mL/min) Lixisenatide is not recommended in severe renal impairment (eGFR below 15 mL/min) Semaglutide, dulaglutide, and liraglutide generally don't require dose adjustment for mild to moderate kidney or liver impairment, but should be used with caution in severe impairment Drug Interactions GLP-1 medications can affect the absorption of oral medications due to delayed gastric emptying
Retatrutide also produces greater visceral fat reduction, stronger metabolic rate effects, and larger improvements in blood sugar markers
This dead volume, typically 0.02 to 0.07 mL depending on the syringe, means you lose a small amount of solution with each draw
