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PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function

5.2 Hypoxic Acid/Base Regulation and Exogenous Buffering Considerations During progressively intense exercise, the drop in muscular pH via hydrogen ion (H + ) production, which is exacerbated by hypoxia at the same absolute workloads, has been shown to negatively affect metabolic processes, such as the inhibition of glycolysis and muscle contraction processes, ultimately resulting in fatigue and decreased performance [123]

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