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Its understanding who will see improvements in blood sugar, heart health, liver disease and kidney function. Long-term questions still remain Hardaway says GLP-1 drugs are essentially supercharged versions of a naturally occurring hormone, and decades of neuroscience research show that receptors can adapt to prolonged stimulation

The data on GLP-1s shows similar effects: The same cellular receptors that the drugs work on in the brain are found in the lungs, and GLP-1s are also thought to calm airway hyper-responsiveness

In the trials, 1.6% of semaglutide patients developed gallstones, compared to 0.7% of placebo patients