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A simple fasting blood test measuring two key incretin hormones could help match patients with severe obesity to the weight-loss medication most likely to work, though researchers say the findings are preliminary and require confirmation in larger clinical trials
However, more research is needed to move from speculation to treatment
This study demonstrated a link between melanin synthesis by melanocytes and DNA damage of keratinocytes through the p53MSHMC1R signalling axis
The source data file underlying all graphs can be found in Supplementary Data
Discontinuation rates from the phase 2 trial due to side effects were generally low, though the broader literature on GLP-1 receptor agonists notes that discontinuation rates across the class can reach 20-50% within the first year
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