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doi: 10.1001/jama.2016.7602 21 Uptodate
ROS can induce damage to both nuclear and mitochondrial DNA through multiple mechanisms and also damage the integrity of mitochondrial permeability transition pore (mPTP), thereby aggravating the dysregulation of mitochondrial dynamics and the control of apoptosis (5052)
it is low in elderly persons
Researchers new to the area often start with the foundational trials cited above before designing their own combination protocols
Having an AAOPM certification or other recognized credential demonstrates clinical competence and can strengthen prior authorization requests and appeal letters
It is more medically honest
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