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Dehydration amplifies every GI side effect

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Although few studies have evaluated the expression of KP metabolites in postmortem samples, TDO protein expression was elevated in white matter glial cells in the anterior cingulate gyrus in samples from MDD patients [61], potentially contributing to localized neuroinflammation

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Sustained GLP-1 signaling also possesses additional benefits: appetite and concomitant weight reduction, and cardioprotective benefits