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Pinch a fold of skin, insert the needle at a 45-90 degree angle (depending on body composition), inject slowly, hold for 5-10 seconds, withdraw the needle straight, and apply gentle pressure if needed

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Importantly, payer reimbursement restrictions are probably in place because previous cost-effectiveness analyses of these medications have considered at least some measure of their glycaemic benefits [13, 14], while whether SGLT2is and GLP-1 RAs are cost-effective solely on the basis of their benefits on cardiovascular and kidney disease has never been studied as far as we are aware

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