pioneer 2 semaglutide Efficacy and safety of once-daily oral 25 mg and 50 mg compared with 14 mg in adults with type diabetes (PIONEER PLUS): a multicentre, randomised, phase 3b trial Post hoc analysis of SUSTAIN

Several GLP-1 agonists have received FDA approval for the treatment of type 2 diabetes

Activation of Gq phospholipase C (PLC) inositol triphosphate (IP3) + diacylglycerol (DAG) mobilization of intracellular calcium stores exocytosis of GH granules

This helps to prevent large blood sugar spikes and crashes, which can lead to increased hunger and cravings

Triplehormone-receptor agonist retatrutide for obesity: A phase 2 trial

Bhaskaran, K., dos-Santos-Silva, I., Leon, D

While discussions at the Weight Management Summit highlighted gradually tapering the dose or increasing time between injections as strategy to manage patient withdrawal symptoms and reduce susceptibility to weight regain and sudden appetite spikes, the consensus was that sustaining metabolic change requires additional effort and assistance