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Studies have shown [11]: Prevention of gastric lesions when co-administered with NSAIDs Healing of existing NSAID-induced damage Protection of both upper and lower GI tract Preservation of intestinal permeability This is particularly significant given that millions of people take NSAIDs regularly, often experiencing GI side effects

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In particular, elective procedures with high consequence complications, including TJA, warrant carefully designed observational cohorts with validated patient-reported outcomes, wound surveillance, and adverse event monitoring

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