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Safety and translational considerations were discussed, including brain penetration after systemic administration

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ClO2, on the other hand, directly attacks the cysteine residues in keratin as well as the inter- and intramolecular disulfide bonds between and within keratin chains, thus acting as a true keratolytic that directly softens keratin and reduces its cohesiveness

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however, work is needed to understand this process and how dietary intake, body weight, genetic predisposition for PDAC, and hyperglycemia promote or inhibit this progression