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Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies
No hepatotoxicity, no cardiovascular signals, no serious adverse events
In human patients, glutathione has been used as a treatment for chronic liver disease, mostly by intravenous administration
Many studies also rely on small sample sizes, underscoring the need for larger, more diverse populations to validate efficacy, safety, and patient compliance
It also plays a role in energy homeostasis and cellular metabolism
Reviews favor oral/topical for safety
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