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TABLE 1 Summary of the mechanisms of action and effects of GLP-1R agonists in AD

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NICE advises that metformin should not normally be started if estimated glomerular filtration rate (eGFR) is below 45 mL/min/1.73m unless the benefits are expected to outweigh the potential risks

Most values were log transformed because they were linearly distributed

The main role of the kidneys is to filter out and excrete waste products from the blood, maintaining fluid and electrolyte balance

Pocernich CB, Butterfield DA