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Retatrutide produced about 24.2% mean weight loss at 48 weeks (Jastreboff et al., 2023), versus roughly 20.9% for tirzepatide at 72 weeks

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doi: 10.1016/j.phrs.2016.12.016 84 PrakosoDLimSYEricksonJRWallaceRSLeesJGTateMet al

This is a big shoe to drop from a validation standpoint

The melanocortin system regulates expression of genes involved in thermogenesis, including uncoupling proteins in brown adipose tissue, contributing to increased energy expenditure independent of physical activity

[PMID: 8205165] PubMed record related to this compound for laboratory literature review