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Conversely, symbiotic gut microflora ( Bifidobacteria, Roseburia and Faecalibacteria ) with prominent immunomodulatory functions, are extinguished from the gut of PASC patients 251

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The core pathological mechanisms of DR are intimately linked to hyperglycemia-induced oxidative stress, with the polyol, hexosamine, protein kinase C (PKC) pathways, and formation of advanced glycation end products (AGEs) representing four central molecular networks (5355)

323 In addition to the above two drugs, asparaginase-targeting drugs include OP-01, JZP-458, ERY-001, and PF-690